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Allele-Specific CRlSPR/Cas9 Chromosomal Rescue for Trisomy 21 P M1 M2 P M1 M2 CRISPR/ 12/4 68 101213 Cas9 U Human cells Allele-specific multiple SpCas9 + gRNA(s) with chromosome cleavages Trisomy 21 M1 M1 Trisomy rescue Loss of the target Corrected gene signatures chromosome